Silva is a nice CMS which is built upon Zope2 and Python. I've done quite a bit of work with it; unfortunately development seems to have died. However, I will leave these pages up in case they prove useful to someone else.
As I've worked with Silva, I've found there are some things that others may find interesting / useful as they use Silva; links are below:
Installing Silva 3.0 on Debian 6 Configuring mod_wsgi and multiple vhosts Upgrading to Silva 3.0